Role of uL3 in the Crosstalk between Nucleolar Stress and Autophagy in Colon Cancer Cells.

ABSTRACT: The nucleolus is the site of ribosome biogenesis and has been recently described as important sensor for a variety of cellular stressors. In the last two decades, it has been largely demonstrated that many chemotherapeutics act by inhibiting early or late rRNA processing steps with consequent alteration of ribosome biogenesis and activation of nucleolar stress response. The overall result is cell cycle arrest and/or apoptotic cell death of cancer cells. Our previously data demonstrated that ribosomal protein uL3 is a key sensor of nucleolar stress activated by common chemotherapeutic agents in cancer cells lacking p53. We have also demonstrated that uL3 status is associated to chemoresistance; down-regulation of uL3 makes some chemotherapeutic drugs ineffective. Here, we demonstrate that i

SUBMITTER: Pecoraro A 

PROVIDER: S-EPMC7139652 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature