Transcriptomic and Network Analysis Identifies Shared and Unique Pathways across Dementia Spectrum Disorders.

ABSTRACT: Dementia is a growing public health concern with an estimated prevalence of 50 million people worldwide. Alzheimer's disease (AD) and vascular and frontotemporal dementias (VaD, FTD), share many clinical, genetical, and pathological features making the diagnosis difficult. In this study, we compared the transcriptome from the frontal cortex of patients with AD, VaD, and FTD to identify dysregulated pathways. Upregulated genes in AD were enriched in adherens and tight junctions, mitogen-activated protein kinase, and phosphatidylinositol 3-kinase and protein kinase B/Akt signaling pathways, whereas downregulated genes associated with calcium signaling. Upregulated genes in VaD were centered on infectious diseases and nuclear factor kappa beta signaling, whereas downregulated genes are involv

SUBMITTER: Santiago JA 

PROVIDER: S-EPMC7139711 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature