Resveratrol in Autism Spectrum Disorders: Behavioral and Molecular Effects.

ABSTRACT: Resveratrol (RSV) is a polyphenolic stillbenoid with significant anti-oxidative and anti-inflammatory properties recently tested in animal models of several neurological diseases. Altered immune alteration and oxidative stress have also been found in patients with autism spectrum disorders (ASD), and these alterations could add to the pathophysiology associated with ASD. We reviewed the current evidence about the effects of RSV administration in animal models and in patients with ASD. RSV administration improves the core-symptoms (social impairment and stereotyped activity) in animal models and it also displays beneficial effects in other behavioral abnormalities such as hyperactivity, anxiety and cognitive function. The molecular mechanisms by which RSV restores or improves behavioral abn

SUBMITTER: Malaguarnera M 

PROVIDER: S-EPMC7139867 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature