Ontology highlight
ABSTRACT:
SUBMITTER: Sarkadi B
PROVIDER: S-EPMC7139890 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Sarkadi Balazs B Meszaros Katalin K Krencz Ildiko I Canu Letizia L Krokker Lilla L Zakarias Sara S Barna Gabor G Sebestyen Anna A Papay Judit J Hujber Zoltan Z Butz Henriett H Darvasi Otto O Igaz Peter P Doczi Judit J Luconi Michaela M Chinopoulos Christos C Patocs Attila A
Cancers 20200305 3
Pheochromocytoma/paragangliomas (Pheo/PGL) are rare endocrine cancers with strong genetic background. Mutations in the <i>SDHB</i> subunit of succinate dehydrogenase (SDH) predispose patients to malignant disease with limited therapeutic options and poor prognosis. Using a host of cellular and molecular biology techniques in 2D and 3D cell culture formats we show that SDH inhibition had cell line specific biological and biochemical consequences. Based on our studies performed on PC12 (rat chroma ...[more]