Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia.

ABSTRACT: Acute myeloid leukemia (AML) is a hematological cancer that mainly affects the elderly. Although complete remission (CR) is achieved for the majority of the patients after induction and consolidation therapies, nearly two-thirds relapse within a short interval. Understanding biological factors that determine relapse has become of major clinical interest in AML. We utilized liquid chromatography tandem mass spectrometry (LC-MS/MS) to identify the protein changes and protein phosphorylation events associated with AML relapse in primary cells from 41 AML patients at time of diagnosis. Patients were defined as relapse-free if they had not relapsed within a five-year clinical follow-up after AML diagnosis. Relapse was associated with increased expression of RNA processing proteins and decreased

SUBMITTER: Aasebo E 

PROVIDER: S-EPMC7140113 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature