Polyclonal lymphocytic infiltrate with arachnoiditis resulting from intrathecal stem cell transplantation.

ABSTRACT: Stem cell treatment outside of studied and approved medical indications can have unforeseen adverse consequences. Here, we present a 74-year-old male that underwent such therapy. The patient presented to our institution with progressive lower extremity weakness and urinary incontinence. He had previously undergone intrathecal stem cell therapy in Moscow, Russia for weakness and fatigue. Magnetic resonance imaging of his thoracic and lumbar spine showed marked enlargement of the cauda equina nerve roots and abnormal mass-like soft tissue involving the thoracolumbar thecal sac. Surgical biopsy of the intrathecal soft tissue showed polyclonal lymphocytic and glial cell proliferation. The patient's symptoms did not improve with medical treatment or radiation, and he is currently under observat

SUBMITTER: Madhavan AA 

PROVIDER: S-EPMC7140295 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature