Variation in base composition underlies functional and evolutionary divergence in non-LTR retrotransposons.

ABSTRACT:

Background

Non-LTR retrotransposons often exhibit base composition that is markedly different from the nucleotide content of their host's gene. For instance, the mammalian L1 element is AT-rich with a strong A bias on the positive strand, which results in a reduced transcription. It is plausible that the A-richness of mammalian L1 is a self-regulatory mechanism reflecting a trade-off between transposition efficiency and the deleterious effect of L1 on its host. We examined if the A-richness of L1 is a general feature of non-LTR retrotransposons or if different clades of elements have evolved different nucleotide content. We also investigated if elements belonging to the same clade evolved towards different base composition in different genomes or if elements from different clades e

SUBMITTER: Ruggiero RP 

PROVIDER: S-EPMC7140322 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature