Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation.

ABSTRACT: Microtubule actin crosslinking factor 1 (MACF1) is a large crosslinker that contributes to cell integrity and cell differentiation. Recent studies show that MACF1 is involved in multiple cellular functions such as neuron development and epidermal migration, and is the molecular basis for many degenerative diseases. MACF1 is highly abundant in bones, especially in mesenchymal stem cells; however, its regulatory role is still less understood in bone formation and degenerative bone diseases. In this study, we found MACF1 expression in mesenchymal stem cells (MSCs) of osteoporotic bone specimens was significantly lower. By conditional gene targeting to delete the mesenchymal Macf1 gene in mice, we observed in MSCs decreased osteogenic differentiation capability. During early stag

SUBMITTER: Zhao F 

PROVIDER: S-EPMC7140458 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature