First trimester use of artemisinin-based combination therapy and the risk of low birth weight and small for gestational age.

ABSTRACT:

Background

While there is increasing evidence on the safety of artemisinin-based combination therapy (ACT) for the case management of malaria in early pregnancy, little is known about the association between exposure to ACT during the first trimester and the effect on fetal growth.

Methods

Data were analysed from prospective studies of pregnant women enrolled in Mozambique, Burkina Faso and Kenya designed to determine the association between anti-malarial drug exposure in the first trimester and pregnancy outcomes, including low birth weight (LBW) and small for gestational age (SGA). Exposure to anti-malarial drugs was ascertained retrospectively by record linkage using a combination of data collected from antenatal and adult outpatient clinic registries, prescription record

SUBMITTER: Augusto O 

PROVIDER: S-EPMC7140480 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature