Cancer Stem Cells: Devil or Savior-Looking behind the Scenes of Immunotherapy Failure.

ABSTRACT: Although the introduction of immunotherapy has tremendously improved the prognosis of patients with metastatic cancers of different histological origins, some tumors fail to respond or develop resistance. Broadening the clinical efficacy of currently available immunotherapy strategies requires an improved understanding of the biological mechanisms underlying cancer immune escape. Globally, tumor cells evade immune attack using two main strategies: avoiding recognition by immune cells and instigating an immunosuppressive tumor microenvironment. Emerging data suggest that the clinical efficacy of chemotherapy or molecularly targeted therapy is related to the ability of these therapies to target cancer stem cells (CSCs). However, little is known about the role of CSCs in mediating tumor resis

SUBMITTER: Castagnoli L 

PROVIDER: S-EPMC7140486 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature