Regulation of KCNMA1 transcription by Nrf2 in coronary arterial smooth muscle cells.

ABSTRACT: The large conductance Ca²⁺-activated K⁺ (BK) channels, composed of the pore-forming α subunits (BK-α, encoded by KCNMA1 gene) and the regulatory β1 subunits (BK-β1, encoded by KCNMB1 gene), play a unique role in the regulation of coronary vascular tone and myocardial perfusion by linking intracellular Ca²⁺ homeostasis with excitation-contraction coupling in coronary arterial smooth muscle cells (SMCs). The nuclear factor erythroid 2-related factor 2 (Nrf2) belongs to a member of basic leucine zipper transcription factor family that regulates the expression of antioxidant and detoxification enzymes by binding to the antioxidant response elements (AREs) of these target genes. We have previously reported that vascular BK-β1 protein expression was tightly regul

SUBMITTER: Sun X 

PROVIDER: S-EPMC7140586 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature