On the TRAIL of Better Therapies: Understanding TNFRSF Structure-Function.

ABSTRACT: Tumor necrosis factor (TNF) superfamily ligands show diverse biological functions, such as the induction of apoptotic cell death or cell survival and proliferation, making them excellent therapeutic targets for cancer and autoimmunity. We review the latest literature on TNF receptor superfamily signaling with a focus on structure-function. Using combinatorics, we argue that receptors that cluster on the cell surface and are activated by membrane-bound ligands need to arrange in a highly ordered manner, as the probability of random ligand and receptor arrangements matching up for receptor activation is very low. A growing body of evidence indicates that antiparallel receptor dimers that sequester the ligand binding site cluster on the cell surface, forming a hexagonal lattice. Upon ligand b

SUBMITTER: Vanamee ES 

PROVIDER: S-EPMC7140660 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature