Ontology highlight
ABSTRACT:
SUBMITTER: Cristofaro I
PROVIDER: S-EPMC7140674 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Cristofaro Ilaria I Alessandrini Francesco F Spinello Zaira Z Guerriero Claudia C Fiore Mario M Caffarelli Elisa E Laneve Pietro P Dini Luciana L Conti Luciano L Tata Ada Maria AM
Cells 20200309 3
Glioblastomas (GBM) are the most aggressive form of primary brain tumors in humans. A key feature of malignant gliomas is their cellular heterogeneity. In particular, the presence of an undifferentiated cell population of defined Glioblastoma Stem cells (GSCs) was reported. Increased expression of anti-apoptotic and chemo-resistance genes in GCSs subpopulation favors their high resistance to a broad spectrum of drugs. Our previous studies showed the ability of M2 muscarinic receptors to negative ...[more]