Citicoline and Vitamin B₁₂ Eye Drops in Type 1 Diabetes: Results of a 3-year Pilot Study Evaluating Morpho-Functional Retinal Changes.

ABSTRACT:

Introduction

This study aimed to evaluate the effect of treatment with eye drops containing citicoline and vitamin B₁₂ on changes in function of the inner retina, morphology of the inner and outer retina, and microvascular condition in patients with type 1 diabetes (DM1) with mild signs of non-proliferative diabetic retinopathy (NPDR) during 3 years of follow-up.

Methods

A pilot study with prospective, randomized, and double-masked design was conducted to address the aims. Twenty patients with DM1 were enrolled and randomly divided into two groups: the DC group comprising patients treated with citicoline and vitamin B₁₂ eye drops (10 patients; mean age ± standard deviation, 46.86 ± 8.78 years) and the DP group comprising those treated with placebo (10 p

SUBMITTER: Parravano M 

PROVIDER: S-EPMC7140741 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature