Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review.

ABSTRACT: Life expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence is a state of cell cycle arrest with suppressed apoptosis and concomitant secretion of multiple bioactive factors (the senescence-associated secretory phenotype-SASP) that plays a physiological role in embryonic development and healing processes. However, DNA damage and oxidative stress that occur during aging cause the accumulation of senescent cells, which through their SASP bring about deleterious effects on multiple organ and systemic functions. Ablation of senescent cells through genetic or

SUBMITTER: Amaya-Montoya M 

PROVIDER: S-EPMC7140757 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature