Intraspecific Genomic Divergence and Minor Structural Variations in Leishmania (Viannia) panamensis.

ABSTRACT: Leishmania (Viannia) panamensis is one of the most important Leishmania species associated with cutaneous leishmaniasis (CL) in Latin America. Despite its wide geographic distribution and pathogenic potential in humans and animals, the genomic variability of this species is low compared with other Leishmania species circulating in the same geographical area. No studies have reported a detailed analysis of the whole genome of L. panamensis from clinical isolates using DNA high-throughput sequencing to clarify its intraspecific genomic variability or plausible divergence. Therefore, this study aimed to evaluate the intraspecific genomic variability of L. panamensis from Colombia and Panama. A total of 22 genomes were analyzed, 19 from Colombian patients wit

SUBMITTER: Patino LH 

PROVIDER: S-EPMC7140786 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature