Network Properties of Cancer Prognostic Gene Signatures in the Human Protein Interactome.

ABSTRACT: Prognostic gene signatures are critical in cancer prognosis assessments and their pinpoint treatments. However, their network properties remain unclear. Here, we obtained nine prognostic gene sets including 1439 prognostic genes of different cancers from related publications. Four network centralities were used to examine the network properties of prognostic genes (PG) compared with other gene sets based on the Human Protein Reference Database (HPRD) and String networks. We also proposed three novel network measures for further investigating the network properties of prognostic gene sets (PGS) besides clustering coefficient. The results showed that PG did not occupy key positions in the human protein interaction network and were more similar to essential genes rather than cancer genes. How

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7140842 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature