Electrical Stimulation Induces Retinal Muller Cell Proliferation and Their Progenitor Cell Potential.

ABSTRACT: Non-invasive electrical stimulation (ES) is increasingly applied to improve vision in untreatable eye conditions, such as retinitis pigmentosa and age-related macular degeneration. Our previous study suggested that ES promoted retinal function and the proliferation of progenitor-like glial cells in mice with inherited photoreceptor degeneration; however, the underlying mechanism remains obscure. Müller cells (MCs) are thought to be dormant residential progenitor cells that possess a high potential for retinal neuron repair and functional plasticity. Here, we showed that ES with a ramp waveform of 20 Hz and 300 µA of current was effective at inducing mouse MC proliferation and enhancing their expression of progenitor cell markers, such as Crx (cone-rod homeobox) and Wnt7, as w

SUBMITTER: Enayati S 

PROVIDER: S-EPMC7140850 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature