The Metabolization Profile of the CYP2D6 Gene in Amerindian Populations: A Review.

ABSTRACT:

Background

the CYP2D6 gene is clinically important and is known to have a number of variants. This gene has four distinct metabolization profiles that are determined by the different allelic forms present in the individual. The relative frequency of these profiles varies considerably among human populations around the world. Populations from more isolated regions, such as Native Americans, are still relatively poorly studied, however. Even so, recent advances in genotyping techniques and increasing interest in the study of these populations has led to a progressive increase in publication rates. Given this, the review presented here compiled the principal papers published on the CYP2D6 gene in Amerindian populations to determine the metabolic profile of this group.

SUBMITTER: Leitao LPC 

PROVIDER: S-EPMC7140882 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature