Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity.

ABSTRACT: Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology and biological mechanisms underlying their comorbidity remain unknown. Here we examined the relationship between endometriosis and migraine using genome-wide association study (GWAS) data. Single nucleotide polymorphism (SNP) effect concordance analysis found a significant concordance of SNP risk effects across endometriosis and migraine GWAS. Linkage disequilibrium score regression analysis found a positive and highly significant genetic correlation (r_G = 0.38, P = 2.30 × 10^-25) between endometriosis and migraine. A meta-analysis of endometriosis and migraine GWAS data did not reveal novel genome

SUBMITTER: Adewuyi EO 

PROVIDER: S-EPMC7140889 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature