Network Mapping of Connectivity Alterations in Disorder of Consciousness: Towards Targeted Neuromodulation.

ABSTRACT: Disorder of consciousness (DoC) refers to a group of clinical conditions that may emerge after brain injury, characterized by a varying decrease in the level of consciousness that can last from days to years. An understanding of its neural correlates is crucial for the conceptualization and application of effective therapeutic interventions. Here we propose a quantitative meta-analysis of the neural substrate of DoC emerging from functional magnetic resonance (fMRI) and positron emission tomography (PET) studies. We also map the relevant networks of resulting areas to highlight similarities with Resting State Networks (RSNs) and hypothesize potential therapeutic solutions leveraging network-targeted noninvasive brain stimulation. Available literature was reviewed and analyzed through the a

SUBMITTER: Mencarelli L 

PROVIDER: S-EPMC7141258 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature