Left Ventricular Noncompaction and Congenital Heart Disease Increases the Risk of Congestive Heart Failure.

ABSTRACT:

Background

Left ventricular noncompaction (LVNC) is a hereditary cardiomyopathy that is associated with high morbidity and mortality rates. Recently, LVNC was classified into several phenotypes including congenital heart disease (CHD). However, although LVNC and CHD are frequently observed, the role and clinical significance of genetics in these cardiomyopathies has not been fully evaluated. Therefore, we aimed to evaluate the impact on the perioperative outcomes of children with concomitant LVNC and CHD using next-generation sequencing (NGS).

Methods

From May 2000 to August 2018, 53 Japanese probands with LVNC (25 males and 28 females) were enrolled and we screened 182 cardiomyopathy-associated genes in these patients using NGS.

Results

The age at diagnosis of the en

SUBMITTER: Hirono K 

PROVIDER: S-EPMC7141335 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature