Tuning a timing device that regulates lateral root development in rice.

ABSTRACT: Peptidyl Prolyl Isomerases (PPIases) accelerate cis-trans isomerization of prolyl peptide bonds. In rice, the PPIase LRT2 is essential for lateral root initiation. LRT2 displays in vitro isomerization of a highly conserved W-P peptide bond (¹⁰⁴W-P¹⁰⁵) in the natural substrate OsIAA11. OsIAA11 is a transcription repressor that, in response to the plant hormone auxin, is targeted to ubiquitin-mediated proteasomal degradation via specific recognition of the cis isomer of its ¹⁰⁴W-P¹⁰⁵ peptide bond. OsIAA11 controls transcription of specific genes, including its own, that are required for lateral root development. This auxin-responsive negative feedback circuit governs patterning and development of lateral roots along the primary root. The ability to

SUBMITTER: Acevedo LA 

PROVIDER: S-EPMC7141409 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature