M⁶A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer.

ABSTRACT: N⁶-Methyladenosine (m⁶A) RNA modification has emerged in recent years as a new layer of regulatory mechanism controlling gene expression in eukaryotes. As a reversible epigenetic modification found not only in messenger RNAs but also in non-coding RNAs, m⁶A affects the fate of the modified RNA molecules and plays important roles in almost all vital bioprocesses, including cancer development. Here we review the up-to-date knowledge of the pathological roles and underlying molecular mechanism of m⁶A modifications (in both coding and non-coding RNAs) in cancer pathogenesis and drug response/resistance, and discuss the therapeutic potential of targeting m⁶A regulators for cancer therapy.

SUBMITTER: Huang H 

PROVIDER: S-EPMC7141420 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature