Early Post-Stroke Infections Are Associated with an Impaired Function of Neutrophil Granulocytes.

ABSTRACT: To investigate whether neutrophil granulocytes' function relates to post-stroke infections and clinical outcome after stroke, we prospectively recruited 95 patients after ischemic stroke and tested them for their microbiocidal neutrophil functions in this exploratory study. Additionally, 24 age-adjusted controls were examined regarding neutrophil function. Phagocytic capacity and the ability of the neutrophil granulocytes to produce reactive oxygen species (ROS) as well as CD11b and CD16 receptor expression profile were measured by flow cytometry at days 1, 3, 7, and 90 after symptom onset. Primary outcome was the development of an infection within the first week after stroke. Results of neutrophil functional measurements were compared between patients with and without infection as well as

SUBMITTER: van Gemmeren T 

PROVIDER: S-EPMC7141520 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature