In vivo implantation of 3-dimensional printed customized branched tissue engineered vascular graft in a porcine model.

ABSTRACT:

Background

The customized vascular graft offers the potential to simplify the surgical procedure, optimize physiological function, and reduce morbidity and mortality. This experiment evaluated the feasibility of a flow dynamic-optimized branched tissue engineered vascular graft (TEVG) customized based on medical imaging and manufactured by 3-dimensional (3D) printing for a porcine model.

Methods

We acquired magnetic resonance angiography and 4-dimensional flow data for the native anatomy of the pigs (n = 2) to design a custom-made branched vascular graft of the pulmonary bifurcation. An optimal shape of the branched vascular graft was designed using a computer-aided design system informed by computational flow dynamics analysis. We manufactured and implanted the graft for pu

SUBMITTER: Yeung E 

PROVIDER: S-EPMC7141946 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature