PTGES/PGE₂ signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model.

ABSTRACT: Chronic inflammation has been linked to promotion of tumorigenesis and metastasis in lung. However, due to lack of a relevant animal model for characterization, the underlying mechanism remains elusive. Lung tumor suppressor gene Gprc5a-knockout (ko) mice are susceptible to lung inflammation, tumorigenesis and metastasis, which resembles the pathological features in human patients. Here, we showed that PTGES/PGE₂ signaling was highly associated with lung tumorigenesis and metastasis in Gprc5a-ko mice. Interestingly, Ptges-knockout in mouse lung tumor cells, although reduced their stemness and EMT-like features, still formed tumors and lung metastasis in immune-deficient nude mice, but not in immune-competent mice. This suggests that the major role of PTGES/PGE₂ signal

SUBMITTER: Wang T 

PROVIDER: S-EPMC7142021 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature