A meta-analysis of mannose-binding lectin gene polymorphisms with the risk of recurrent vulvovaginal infections.

ABSTRACT: The genetic variants of Mannose-Binding Lectin, a vital component of innate immunity have been studied with acute/recurrent vaginal infections ((R)VVI) and presented inconclusive findings. Therefore, a systematic review and meta-analysis of published data were conducted to assess the possible role of these variations in (R)VVI. A comprehensive search was made using PubMed, Web of Science and Google scholar till June 18, 2019. A total of 12 studies met the specified criteria and were included in the analysis. Different comparisons were made on the basis of the outcome of interest that resulted in the filtering of studies for the pooled analysis to find an association using the standard genetic models. Odds ratio (OR) with 95% confidence interval (CI) was chosen as the effect measure for the

SUBMITTER: Kalia N 

PROVIDER: S-EPMC7142065 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature