An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy.

ABSTRACT: The therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage of oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H₂O₂) in chemodynamic therapy (CDT). Here, we report a H₂O₂/O₂ self-supplying nanoagent, (MSNs@CaO₂-ICG)@LA, which consists of manganese silicate (MSN)-supported calcium peroxide (CaO₂) and indocyanine green (ICG) with further surface modification of phase-change material lauric acid (LA). Under laser irradiation, ICG simultaneously generates singlet oxygen and emits heat to melt the LA. The exposed CaO₂ reacts with water to produce O₂ and H₂O₂ for hypoxi

SUBMITTER: Liu C 

PROVIDER: S-EPMC7142144 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature