Larval Geoduck (Panopea generosa) Proteomic Response to Ciliates.

ABSTRACT: The innate immune response is active in invertebrate larvae from early development. Induction of immune response pathways may occur as part of the natural progression of larval development, but an up-regulation of pathways can also occur in response to a pathogen. Here, we took advantage of a protozoan ciliate infestation of a larval geoduck clam culture in a commercial hatchery to investigate the molecular underpinnings of the innate immune response of the larvae to the pathogen. Larval proteomes were analyzed on days 4-10 post-fertilization; ciliates were present on days 8 and 10 post-fertilization. Through comparisons with larval cultures that did not encounter ciliates, proteins implicated in the response to ciliate presence were identified using mass spectrometry-based proteomics. Cil

SUBMITTER: Timmins-Schiffman E 

PROVIDER: S-EPMC7142153 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature