Integrating Biological Advances Into the Clinical Management of Breast Cancer Related Lymphedema.

ABSTRACT: Breast cancer-related lymphedema (BCRL) occurs in a significant number of breast cancer survivors as a consequence of the axillary lymphatics' impairment after therapy (mainly axillary surgery and irradiation). Despite the recent achievements in the clinical management of these patients, BCRL is often diagnosed at its occurrence. In most cases, it remains a progressive and irreversible condition, with dramatic consequences in terms of quality of life and on sanitary costs. There are still no validated pre-surgical strategies to identify individuals that harbor an increased risk of BCRL. However, clinical, therapeutic, and tumor-specific traits are recurrent in these patients. Over the past few years, many studies have unraveled the complexity of the molecular and transcriptional events lea

SUBMITTER: Invernizzi M 

PROVIDER: S-EPMC7142240 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature