Regulation of Antimycin Biosynthesis Is Controlled by the ClpXP Protease.

ABSTRACT: The survival of any microbe relies on its ability to respond to environmental change. Use of extracytoplasmic function (ECF) RNA polymerase sigma (σ) factors is a major strategy enabling dynamic responses to extracellular signals. Streptomyces species harbor a large number of ECF σ factors, nearly all of which are uncharacterized, but those that have been characterized generally regulate genes required for morphological differentiation and/or response to environmental stress, except for σ^AntA, which regulates starter-unit biosynthesis in the production of antimycin, an anticancer compound. Unlike a canonical ECF σ factor, whose activity is regulated by a cognate anti-σ factor, σ^AntA is an orphan, raising intriguing questions about how its a

SUBMITTER: Bilyk B 

PROVIDER: S-EPMC7142297 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature