Anti-inflammatory Gut Microbial Pathways Are Decreased During Crohn's Disease Exacerbations.

ABSTRACT:

Background and aims

Crohn's disease [CD] is a chronic inflammatory disorder of the gastrointestinal tract characterised by alternating periods of exacerbation and remission. We hypothesised that changes in the gut microbiome are associated with CD exacerbations, and therefore aimed to correlate multiple gut microbiome features to CD disease activity.

Methods

Faecal microbiome data generated using whole-genome metagenomic shotgun sequencing of 196 CD patients were of obtained from the 1000IBD cohort [one sample per patient]. Patient disease activity status at time of sampling was determined by re-assessing clinical records 3 years after faecal sample production. Faecal samples were designated as taken 'in an exacerbation' or 'in remission'. Samples taken 'in remission' were f

SUBMITTER: Klaassen MAY 

PROVIDER: S-EPMC7142399 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature