Metabolic Profiling of Glucose-Fed Metabolically Active Resting Zymomonas mobilis Strains.

ABSTRACT: Zymomonas mobilis is the most efficient bacterial ethanol producer and its physiology is potentially applicable to industrial-scale bioethanol production. However, compared to other industrially important microorganisms, the Z. mobilis metabolome and adaptation to various nutritional and genetic perturbations have been poorly characterized. For rational metabolic engineering, it is essential to understand how central metabolism and intracellular redox balance are maintained in Z. mobilis under various conditions. In this study, we applied quantitative mass spectrometry-based metabolomics to explore how glucose-fed non-growing Z. mobilis Zm6 cells metabolically adapt to change of oxygen availability. Mutants partially impaired in ethanol synthesis (Zm6 adhB) or oxidative stress response (Zm

SUBMITTER: Fuchino K 

PROVIDER: S-EPMC7142471 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature