Analysis and Simulation of Glioblastoma Cell Lines-Derived Extracellular Vesicles Metabolome.

ABSTRACT: Glioblastoma (GBM) is one of the most aggressive cancers of the central nervous system. Despite current advances in non-invasive imaging and the advent of novel therapeutic modalities, patient survival remains very low. There is a critical need for the development of effective biomarkers for GBM diagnosis and therapeutic monitoring. Extracellular vesicles (EVs) produced by GBM tumors have been shown to play an important role in cellular communication and modulation of the tumor microenvironment. As GBM-derived EVs contain specific "molecular signatures" of their parental cells and are able to transmigrate across the blood-brain barrier into biofluids such as the blood and cerebrospinal fluid (CSF), they are considered as a valuable source of potential diagnostic biomarkers. Given the relat

SUBMITTER: Cuperlovic-Culf M 

PROVIDER: S-EPMC7142482 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature