Reconstruction and Analysis of Cattle Metabolic Networks in Normal and Acidosis Rumen Tissue.

ABSTRACT: The objective of this study was to develop a system-level understanding of acidosis biology. Therefore, the genes expression differences between the normal and acidosis rumen epithelial tissues were first examined using the RNA-seq data in order to understand the molecular mechanisms involved in the disease and then their corresponding metabolic networks constructed. A number of 1074 genes, 978 isoforms, 1049 transcription start sites (TSS), 998 coding DNA sequence (CDS) and 2 promoters were identified being differentially expressed in the rumen tissue between the normal and acidosis samples (p < 0.05). The functional analysis of 627 up-regulated genes revealed their involvement in ion transmembrane transport, filament organization, regulation of cell adhesion, regulation of the act

SUBMITTER: Gholizadeh M 

PROVIDER: S-EPMC7142512 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature