Antimalarial Peptide and Polyketide Natural Products from the Fijian Marine Cyanobacterium Moorea producens.

ABSTRACT: A new cyclic peptide, kakeromamide B (1), and previously described cytotoxic cyanobacterial natural products ulongamide A (2), lyngbyabellin A (3), 18E-lyngbyaloside C (4), and lyngbyaloside (5) were identified from an antimalarial extract of the Fijian marine cyanobacterium Moorea producens. Compounds 1 and 1 exhibited moderate activity against Plasmodium falciparum blood-stages with EC₅₀ values of 0.89 and 0.99 µM, respectively, whereas 3 was more potent with an EC₅₀ value of 0.15 nM, respectively. Compounds 1, 4, and 5 displayed moderate liver-stage antimalarial activity against P. berghei liver schizonts with EC₅₀ values of 1.1, 0.71, and 0.45 µM, re

SUBMITTER: Sweeney-Jones AM 

PROVIDER: S-EPMC7142784 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature