Protein Aggregation is Associated with Acinetobacter baumannii Desiccation Tolerance.

ABSTRACT: Desiccation tolerance has been implicated as an important characteristic that potentiates the spread of the bacterial pathogen Acinetobacter baumannii on dry surfaces. Here we explore several factors influencing desiccation survival of A. baumannii. At the macroscale level, we find that desiccation tolerance is influenced by cell density and growth phase. A transcriptome analysis indicates that desiccation represents a unique state for A. baumannii compared to commonly studied growth phases and strongly influences pathways responsible for proteostasis. Remarkably, we find that an increase in total cellular protein aggregates, which is often considered deleterious, correlates positively with the ability of A. baumannii to survive desiccation. We show that inducing protein aggregate formatio

SUBMITTER: Wang X 

PROVIDER: S-EPMC7142981 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature