A Microfluidic Concentration Gradient Maker with Tunable Concentration Profiles by Changing Feed Flow Rate Ratios.

ABSTRACT: Microfluidic chips-in which chemical or biological fluid samples are mixed into linear or nonlinear concentration distribution profiles-have generated enormous enthusiasm of their ability to develop patterns for drug release and their potential toxicology applications. These microfluidic devices have untapped potential for varying concentration patterns by the use of one single device or by easy-to-operate procedures. To address this challenge, we developed a soft-lithography-fabricated microfluidic platform that enabled one single device to be used as a concentration maker, which could generate linear, bell-type, or even S-type concentration profiles by tuning the feed flow rate ratios of each independent inlet. Here, we present an FFRR (feed flow rate ratio) adjustment approach to genera

SUBMITTER: Zhang T 

PROVIDER: S-EPMC7142998 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature