Genome-Wide Association Study Reveals Candidate Genes for Litter Size Traits in Pelibuey Sheep.

ABSTRACT: The Pelibuey sheep has adaptability to climatic variations, resistance to parasites, and good maternal ability, whereas some ewes present multiple births, which increases the litter size in farm sheep. The litter size in some wool sheep breeds is associated with the presence of mutations, mainly in the family of the transforming growth factor β (TGF-β) genes. To explore genetic mechanisms underlying the variation in litter size, we conducted a genome-wide association study in two groups of Pelibuey sheep (multiparous sheep with two lambs per birth vs. uniparous sheep with a single lamb at birth) using the OvineSNP50 BeadChip. We identified a total of 57 putative SNPs markers (p < 3.0 × 10^-3, Bonferroni correction). The candidate genes that may be associated with litter si

SUBMITTER: Hernandez-Montiel W 

PROVIDER: S-EPMC7143297 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature