Marine Toxins Targeting Kv1 Channels: Pharmacological Tools and Therapeutic Scaffolds.

ABSTRACT: Toxins from marine animals provide molecular tools for the study of many ion channels, including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity profiling and molecular investigation of these toxins have contributed to the development of novel drug leads with therapeutic potential for the treatment of ion channel-related diseases or channelopathies. Here, we review specific peptide and small-molecule marine toxins modulating Kv1 channels and thus cover recent findings of bioactives found in the venoms of marine Gastropod (cone snails), Cnidarian (sea anemones), and small compounds from cyanobacteria. Furthermore, we discuss pivotal advancements at exploiting the interaction of κM-conotoxin RIIIJ and heteromeric Kv1.1/1.2 channels as prevalent neuronal Kv complex.

SUBMITTER: Finol-Urdaneta RK 

PROVIDER: S-EPMC7143316 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature