Proteomic Adaptation of Streptococcus pneumoniae to the Human Antimicrobial Peptide LL-37.

ABSTRACT: Secreted antimicrobial peptides (AMPs) are an important part of the human innate immune system and prevent local and systemic infections by inhibiting bacterial growth in a concentration-dependent manner. In the respiratory tract, the cationic peptide LL-37 is one of the most abundant AMPs and capable of building pore complexes in usually negatively charged bacterial membranes, leading to the destruction of bacteria. However, the adaptation mechanisms of several pathogens to LL-37 are already described and are known to weaken the antimicrobial effect of the AMP, for instance, by repulsion, export or degradation of the peptide. This study examines proteome-wide changes in Streptococcus pneumoniae D39, the leading cause of bacterial pneumonia, in response to physiological concentratio

SUBMITTER: Mucke PA 

PROVIDER: S-EPMC7143398 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature