Fitness Cost of <i>bla</i>_NDM-5-Carrying p3R-IncX3 Plasmids in Wild-Type NDM-Free <i>Enterobacteriaceae</i>.

ABSTRACT: The wide dissemination of New Delhi metallo-β-lactamase genes (bla_NDM) has resulted in the treatment failure of most available β-lactam antibiotics, with IncX3-type bla_NDM-5-carrying plasmids recognised as having spread worldwide. In China, bacteria carrying these plasmids are increasingly being detected from diverse samples, including hospitals, communities, livestock and poultry, and the environment, suggesting that IncX3 plasmids are becoming a vital vehicle for bla_NDM dissemination. To elucidate the fitness cost of these plasmids on the bacterial host, we collected bla_NDM-negative strains from different sources and tested their ability to acquire the bla_NDM-5-harboring p3R-IncX3 plasmid. We then m

SUBMITTER: Ma T 

PROVIDER: S-EPMC7143814 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature