Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations.

ABSTRACT:

Background

Evidence suggests that pathophysiological conditions such as obesity and type 2 diabetes (T2D) are associated with morphologic and metabolic alterations in the small intestinal mucosa. Exploring these alterations generally requires invasive methods, limiting data acquisition to subjects with enteropathies or undergoing bariatric surgery. We aimed to evaluate small intestine epithelial cell homeostasis in a cohort of men covering a wide range of adiposity and glucose homoeostasis statuses.

Methods

Plasma levels of citrulline, a biomarker of enterocyte mass, and I-FABP, a biomarker of enterocyte death, were measured by UHPLC‑MS and ELISA in 154 nondiabetic men and 67 men with a T2D diagnosis.

Results

Plasma citrulline was significantly reduced in men with ins

SUBMITTER: Lalande C 

PROVIDER: S-EPMC7144049 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature