Global Transcriptome Changes That Accompany Alterations in Serotonin Levels in Caenorhabditis elegans.

ABSTRACT: Serotonin (5-hydroxytryptamine, 5-HT), is a phylogenetically ancient molecule best characterized as a neurotransmitter that modulates multiple aspects of mood and social cognition. The roles that 5-HT plays in normal and abnormal behavior are not fully understood but have been posited to be due to its common function as a 'defense signal'. However, 5-HT levels also systemically impact cell physiology, modulating cell division, migration, apoptosis, mitochondrial biogenesis, cellular metabolism and differentiation. Whether these diverse cellular effects of 5-HT also share a common basis is unclear. C. elegans provides an ideal system to interrogate the systemic effects of 5-HT, since lacking a blood-brain barrier, 5-HT synthesized and released by neurons permeates the organism to mod

SUBMITTER: Cruz-Corchado J 

PROVIDER: S-EPMC7144078 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature