Electrocoalescence of Water-in-Oil Droplets with a Continuous Aqueous Phase: Implementation of Controlled Content Release.

ABSTRACT: Droplet-based microfluidics have emerged as an important tool for diverse biomedical and biological applications including, but not limited to, drug screening, cellular analysis, and bottom-up synthetic biology. Each microfluidic water-in-oil droplet contains a well-defined biocontent that, following its manipulation/maturation, has to be released into a physiological environment toward possible end-user investigations. Despite the progress made in recent years, considerable challenges still loom at achieving a precise control over the content release with sufficient speed and sensitivity. Here, we present a quantitative study in which we compare the effectiveness and biocompatibility of chemical and physical microfluidic release methods. We show the advantages of electrocoalescence of wat

SUBMITTER: Frey C 

PROVIDER: S-EPMC7144163 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature