HIV drug resistance in a cohort of HIV-infected MSM in the United States.

ABSTRACT:

Objective

To analyze HIV drug resistance among MSM recruited for participation in the HPTN 078 study, which evaluated methods for achieving and maintaining viral suppression in HIV-infected MSM.

Methods

Individuals were recruited at four study sites in the United States (Atlanta, Georgia; Baltimore, Maryland; Birmingham, Alabama; and Boston, Massachusetts; 2016-2017). HIV genotyping was performed using samples collected at study screening or enrollment. HIV drug resistance was evaluated using the Stanford v8.7 algorithm. A multiassay algorithm was used to identify individuals with recent HIV infection. Clustering of HIV sequences was evaluated using phylogenetic methods.

Results

High-level HIV drug resistance was detected in 44 (31%) of 142 individuals (Atlanta: 21%,

SUBMITTER: Fogel JM 

PROVIDER: S-EPMC7144622 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature