Is the Association of Early Day Care Attendance with Childhood Asthma Explained by Underlying Susceptibility?

ABSTRACT:

Background

Previous studies of early day care attendance and asthma development are inconsistent, which may be explained by inadequate control of confounding and effect modification. We examined the effect of early day care on the risk of asthma taking into account the underlying susceptibility to asthma.

Methods

The study included 55,404 children participating in the Norwegian Mother, Father and Child Cohort Study. Asthma at age 7 was defined by dispensed asthma medications in the Norwegian Prescription Database. We defined a disease risk score (DRS) to account for an underlying susceptibility to asthma including a range of hereditary and nonhereditary predictors of asthma. We assessed confounding and modifying effects of DRS on the association between day care and asthma.<

SUBMITTER: Rantala AK 

PROVIDER: S-EPMC7144755 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature