Ontology highlight
ABSTRACT:
SUBMITTER: Hou L
PROVIDER: S-EPMC7144947 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nucleic acids research 20200401 7
Some transcription factors that specifically bind double-stranded DNA appear to also function as RNA-binding proteins. Here, we demonstrate that the transcription factor Sox2 is able to directly bind RNA in vitro as well as in mouse and human cells. Sox2 targets RNA via a 60-amino-acid RNA binding motif (RBM) positioned C-terminally of the DNA binding high mobility group (HMG) box. Sox2 can associate with RNA and DNA simultaneously to form ternary RNA/Sox2/DNA complexes. Deletion of the RBM does ...[more]