MicroRNA-320a Monitors Intestinal Disease Activity in Patients With Inflammatory Bowel Disease.

ABSTRACT:

Objectives

In patients with inflammatory bowel disease (IBD), a treat-to-target treatment strategy requires tight monitoring of disease activity. Noninvasive biomarkers may help to monitor the intestinal disease activity. We demonstrated recently that peripheral microRNA (miR)-320a expression in mice follows the course of experimental colitis. The aim of this study was to evaluate the potential of miR-320a to monitor the disease activity in patients with IBD, to predict the course of disease, and to distinguish IBD from infectious colitis.

Methods

The miR-320a levels were prospectively assessed by quantitative real-time polymerase chain reaction analysis of peripheral blood samples from 40 patients with Crohn's disease (CD) and 37 patients with ulcerative colitis (UC) as wel

SUBMITTER: Cordes F 

PROVIDER: S-EPMC7145033 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature